PureNeem Night Care
Rejuvence Night Cream
Repair. Firm. Renew — while you sleep.
A clinical-strength overnight cream powered by retinol, ceramides, and a triple-peptide complex — designed to accelerate cell turnover, rebuild the barrier, and restore firmness and elasticity by morning.
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Overnight Renewal
Clinical actives working while you sleep.
Retinol accelerates cell turnover and smooths fine lines. Ceramides rebuild the lipid barrier overnight. A triple-peptide complex including Tetrapeptide-38 signals deep collagen production. Neem, licorice root, and green tea provide Ayurvedic antioxidant defence until morning.
Renews
Repair
Texture
Apply every evening as the final step of your nighttime routine. Wake up to visibly smoother, firmer skin.
Aqua, Caprylic Capric Triglyceride, Dicaprylyl Carbonate, Glycerine, Glyceryl Mono Stearate, Stearic Acid, Cetearyl Alcohol (and) Cetearyl Glucoside, Glyceryl Stearate (and) Peg-100 Stearate, Polyacrylate-13 (and) Polyisobutene (and) Polysorbate 20, Butyrospermum Parkii, Simmondsia Chinensis (Jojoba) Seed Oil, Pentylene Glycol (and) Tamarindus Indica Seed Gum, Ethyl Ascorbic Acid, Melia Azadirachta (Neem) Extract, Retinol, Xanthan Gum, Glycyrrhiza Glabra (Licorice) Root Extract, Camellia Sinensis (Green Tea) Leaf Extract, Vitis Vinifera (Grape) Leaf Extract, Ceramide, Aluminum Starch Octenylsuccinate, Glycerin (and) Aqua (and) Butylene Glycol (and) Carbomer (and) Polysorbate 20 (and) Palmitoyl Tripeptide-1 (and) Palmitoyl Tetrapeptide-7, Xylitylglucoside (and) Anhydroxylitol (and) Xylitol, Palmitoyl Tetrapeptide-38, Tocopheryl Acetate, Phenoxyethanol, Triethylene Glycol, Sodium Gluconate, Allantoin.
Intensely hydrates, improves skin elasticity, reduces fine lines, brightens uneven tone, and revitalizes the skin with a powerful blend of retinol, ceramides, and peptides.
Suitable for all skin types, including normal, dry, and combination skin. Ideal for those seeking to address early signs of aging, improve elasticity, and enhance overall radiance.
For sensitive or oily skin, introduce gradually to assess tolerance. Conduct a patch test before first use to ensure compatibility
After cleansing and toning, apply a pea-sized amount of the cream to your face and neck. Gently massage in upward motions until fully absorbed. For best results, use twice daily—morning and night.
Follow with sunscreen during the day to protect skin from sun damage.
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Your skin repairs at night.
This cream makes it count.
Retinol, ceramides, and a triple-peptide complex — clinically chosen to work when your skin's repair mechanisms are most active.
Not just a moisturiser. An overnight treatment.
Most night creams sit on the surface and hydrate. Rejuvence goes deeper. Retinol accelerates cell turnover while you sleep. A triple-peptide complex — including next-generation Tetrapeptide-38 — signals collagen production at the dermal junction. Ceramides rebuild the lipid barrier overnight. Neem, licorice root, and green tea provide Ayurvedic antioxidant defence until morning. You wake up to skin that's visibly smoother, firmer, and more resilient.
Retinol triggers rapid cell turnover — pushing fresh, undamaged skin to the surface while smoothing fine lines, fading dark spots, and refining texture overnight.
Three clinical peptides — Tripeptide-1, Tetrapeptide-7, and Tetrapeptide-38 — signal collagen synthesis and reduce micro-inflammation at the deepest structural level.
Ceramides, shea butter, and jojoba rebuild the lipid barrier while you sleep — locking in every active and preventing overnight moisture loss.
Designed for skin that's ready to renew.
Rejuvence works across skin types — but it's especially transformative for anyone noticing the early signs of ageing or wanting to get ahead of them.
The power of retinol.
Without the drama.
Retinol has a reputation — and not always a good one. Redness, peeling, irritation. Rejuvence was formulated to change that. The retinol is carefully buffered by ceramides that protect the barrier, allantoin that calms sensitivity, and peptides that strengthen the skin while it renews. The benefit of skincare's most respected active — without your skin paying the price.
Four steps. Every evening.
Every ingredient. Decoded.
Tap any category to explore, then tap an ingredient to see exactly what it does.
Every ingredient, independently verified. Rated by Paula's Choice — one of the most trusted independent skincare research platforms.
Ingredient Checker (Paula's Choice Skincare)Frequently asked.
Every active named. Every mechanism explained. Every claim transparent and traceable.
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Rejuvence is formulated for normal, dry, mature, and combination skin showing signs of aging — fine lines, loss of firmness, dullness, and uneven texture.
The blend of Ceramide, the Palmitoyl Tetrapeptide-38 + Tripeptide-1 + Tetrapeptide-7 peptide complex, and botanical extracts (Neem, Licorice Root, Green Tea, Grape Leaf) makes the formulation nourishing yet lightweight, suitable even for sensitive skin when introduced gradually.
Skin showing early or advanced signs of aging will see the most visible benefit.
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Yes — Rejuvence is designed for nightly use once your skin has adjusted to the formulation.
If you're new to retinol or have sensitive skin: start with two nights per week for the first 2 weeks. Increase to alternate nights for the next 2 weeks. By week 5, most users tolerate nightly use comfortably. This gradual introduction is called retinol acclimation — it allows the skin barrier to adapt to accelerated cell turnover without irritation.
Rejuvence is formulated with Ceramide, Allantoin, Shea Butter, and Jojoba Oil specifically to buffer the dryness and reactivity commonly associated with retinol introduction.
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Yes. Rejuvence is built around the most extensively researched topical anti-aging actives in dermatological literature, working through four distinct pathways:
- Retinol (Vitamin A) — accelerates cellular turnover, smooths surface texture, refines fine lines, and supports collagen production over sustained use
- Palmitoyl Tetrapeptide-38 — advanced matrikine signal peptide engineered to support collagen, hyaluronic acid, and laminin production (three foundational dermal matrix proteins)
- Palmitoyl Tripeptide-1 + Tetrapeptide-7 — dual-action peptide pairing supporting collagen synthesis while limiting glycation damage that contributes to skin stiffness over time
- Ethyl Ascorbic Acid — stable Vitamin C derivative supporting overnight antioxidant defense and brightening
This four-pathway anti-aging system is why Rejuvence is PureNeem's anti-aging hero — formulated for visible improvements in firmness, fine lines, and skin renewal quality.
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Yes. Rejuvence delivers brightening through three complementary pathways:
- Retinol accelerates cell turnover, naturally fading surface pigmentation and dullness over time
- Ethyl Ascorbic Acid (stable Vitamin C derivative) provides overnight antioxidant defense and tone correction
- Glycyrrhiza Glabra (Licorice) Root Extract and Melia Azadirachta (Neem) Extract are Ayurvedic botanicals traditionally used for radiance and skin clarity
For dedicated daytime brightening targeting hyperpigmentation, Alpha Arbutin, and Tetrapeptide-30, pair Rejuvence (evening) with PureNeem Luminara C Radiance Serum in the morning. The combination addresses brightening across both circadian phases.
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Yes — with gradual introduction. Rejuvence is formulated specifically to support sensitive complexions through retinol acclimation:
- Camellia Sinensis (Green Tea) Leaf Extract calms reactivity and provides antioxidant defense
- Allantoin soothes irritation and supports recovery
- Simmondsia Chinensis (Jojoba) Seed Oil mimics skin's natural sebum to maintain barrier balance
- Ceramide + Butyrospermum Parkii (Shea Butter) rebuild the skin barrier overnight
Patch test before first use. Start with 2 applications per week for the first 2 weeks, increasing gradually. Discontinue and consult a dermatologist if persistent irritation occurs.
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No artificial fragrances are added. The light, pleasant scent comes naturally from the botanical extracts — Glycyrrhiza Glabra (Licorice) Root, Camellia Sinensis (Green Tea), and Vitis Vinifera (Grape) Leaf.
This botanical scent profile is significantly gentler than synthetic fragrance compounds, which are a common irritant for sensitive skin in anti-aging products.
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Evening only is strongly recommended. Retinol increases skin sensitivity to UV radiation — daytime use without strict sun protection accelerates the photodamage retinol is meant to repair.
If circumstances require daytime application, you must follow with broad-spectrum SPF 30+ sunscreen and reapply throughout the day. The same SPF discipline is required during evening-only use as well — retinol creates a 24-hour photosensitivity window.
This is non-negotiable. Retinol use without daily SPF causes more visible photodamage than not using retinol at all.
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Rejuvence delivers hydration through five distinct mechanisms — critical because retinol is naturally drying when used alone:
- Ceramide — lipid molecule structurally identical to those in the skin barrier, restores moisture retention and reduces overnight transepidermal water loss
- Glycerin — humectant that draws moisture into the skin
- Tamarind Seed Gum + Pentylene Glycol — natural polysaccharide hydration system
- Xylitylglucoside / Anhydroxylitol / Xylitol complex — botanical hydration triple delivering hydration to deeper skin layers
- Simmondsia Chinensis (Jojoba) Seed Oil + Butyrospermum Parkii (Shea) Butter — barrier-replenishing emollients
This multi-pathway hydration framework is what allows Rejuvence to deliver retinol efficacy without the dryness most retinol products cause.
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No. Rejuvence is non-comedogenic — formulated to deliver hydration and anti-aging benefits without clogging pores or triggering breakouts.
The carrier oil (Caprylic/Capric Triglyceride) and emollient (Dicaprylyl Carbonate) are deliberately chosen for their lightweight, non-comedogenic profiles. Simmondsia Chinensis (Jojoba) Seed Oil mimics the skin's natural sebum, balancing oil production rather than clogging pores. Retinol itself is also known to support clearer skin over time by accelerating cell turnover that prevents pore congestion.
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Week 1: Skin feels smoother and more hydrated. Some users may experience mild dryness or flaking — this is normal during retinol acclimation.
Weeks 4-6: Visible improvements in skin texture, brightness, and refinement of fine lines. Skin barrier feels stronger and more resilient.
Weeks 8-12: Sustained improvements in firmness, deeper line refinement, and overall skin renewal quality as collagen production responds to consistent retinol and peptide signaling.
Anti-aging is a long-term clinical pathway — the most dramatic results compound over months of consistent use, not days.
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A 100g jar of Rejuvence typically lasts 6-8 weeks with regular nightly use. A pea-sized amount provides full-face coverage; using more does not improve results and risks unnecessary irritation.
Storage: store in a cool, dry place away from direct sunlight and heat. High temperatures and humidity degrade the potency of Retinol and Ethyl Ascorbic Acid — bathroom shelves are not ideal due to humidity exposure.
Close the lid tightly after each use. Discard 6 months after opening for retinol potency, even if product remains.
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All three are forms of Vitamin A — they differ in potency, conversion pathway, and how aggressively they work on the skin:
- Retinoids — the umbrella term for all Vitamin A derivatives. Includes prescription tretinoin (the most aggressive), retinaldehyde, retinol, and retinyl esters
- Retinol — the form used in Rejuvence. Converts to retinoic acid in the skin via two enzymatic conversion steps. Significantly more tolerable than prescription tretinoin while delivering the same long-term anti-aging benefits over sustained use
- Retinal (Retinaldehyde) — one step closer to retinoic acid than retinol; faster-acting but less stable in formulation, often more irritating
- Tretinoin (prescription only) — pure retinoic acid; works fastest but requires medical supervision and causes substantial initial irritation
Rejuvence uses Retinol deliberately — it provides clinical-grade anti-aging benefits without prescription requirement, prescription-tier irritation, or the formulation instability of retinaldehyde. The Ceramide + Allantoin + Jojoba + Shea Butter buffer system is engineered specifically to support sustained retinol use without the typical retinol downsides.
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Most anti-aging creams take one of two approaches: a single-active retinol formula (which often delivers retinol without the support system to tolerate it), or a botanical "natural anti-aging" formula (which markets heritage claims without naming clinical actives or concentrations).
Rejuvence is built on four named clinical anti-aging actives working together:
- Retinol for accelerated cell turnover
- Palmitoyl Tetrapeptide-38 for collagen, hyaluronic acid, and laminin support
- Palmitoyl Tripeptide-1 + Tetrapeptide-7 for collagen synthesis and anti-glycation
- Ethyl Ascorbic Acid for overnight antioxidant defense
Layered with Ayurvedic botanicals (Neem, Licorice Root, Green Tea, Grape Leaf) — PureNeem's Ayurvedic-clinical fusion philosophy in anti-aging form.
Full INCI transparency: every active is disclosed by name. Concentrations follow INCI ordering rather than being hidden behind "proprietary complexes." Clinical-grade active concentrations benchmarked against luxury anti-aging ranges, delivered at accessible direct-to-consumer pricing without the retail markup.
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Yes — with the right sequencing. Rejuvence is engineered to work alongside other actives without conflict:
- Vitamin C (morning) + Retinol (evening): the gold-standard anti-aging routine. Pair Rejuvence at night with PureNeem Luminara C Radiance Serum in the morning. Vitamin C provides daytime antioxidant defense; retinol provides overnight cellular renewal
- Peptide products: Rejuvence already contains a triple-peptide complex. Additional peptide layering is generally redundant rather than complementary
- AHAs / BHAs: never simultaneously with retinol — combined acidity compromises the skin barrier. Use exfoliants on alternate evenings or in the morning
- Hydrating creams: PureNeem Mucina Silk Hydration Cream can be layered over Rejuvence on nights when skin needs additional barrier support, particularly during retinol acclimation
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Retinol introduction follows a clinical protocol called retinol acclimation. The goal is to allow your skin barrier to adapt to accelerated cell turnover without triggering the irritation, dryness, or "retinol uglies" that cause most users to abandon retinol prematurely.
The Rejuvence Acclimation Protocol:
- Weeks 1-2: Apply twice per week, on non-consecutive nights (e.g. Tuesday and Friday). Pea-sized amount, full face except eye area
- Weeks 3-4: Increase to alternate nights (every other night)
- Week 5 onwards: Most users tolerate nightly use comfortably by this stage
Critical companion habits:
- Apply to completely dry skin — damp skin amplifies retinol penetration and increases irritation risk
- Wait 10-15 minutes after cleansing before application
- Layer PureNeem Mucina Silk Hydration Cream over Rejuvence on dry-feeling nights for additional barrier support
- Daily broad-spectrum SPF 30+ is non-negotiable — retinol creates 24-hour photosensitivity
If you experience persistent irritation, redness, or flaking that doesn't resolve within 2 weeks, discontinue use and consult a dermatologist. Most retinol-naive users adapt within 4-6 weeks.


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